The present disclosure relates to a composition for preventing, alleviating or treating stress diseases, containing a Platycodon grandiflorum extract as an active ingredient, and, more specifically, to a food composition for preventing or alleviating stress diseases or a pharmaceutical composition for preventing and treating stress diseases, both of which contain a Platycodon grandiflorum extract and a Citrus aurantium extract as active ingredients. A method of the present disclosure can be used for the preparation of an agent for treating depression and anxiety, which are stress diseases, with few side effects because of the use of a natural material, and a health functional food having effects of alleviating depression, anxiety and fatigue, which are stress diseases.