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Bicyclic Derivatives of Pyridine
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
BERND BUETTELMANN,AURELIA CONTE,HOLGER KUEHNE,BERND KUHN,WERNER NEIDHART,ULRIKE OBST SANDER,HANS RICHTER
申请号:
ARP130103005
公开号:
AR092223A1
申请日:
2013.08.26
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
It includes the composition of the compound and the method of using the compound. 1. Characteristic 1: compound of formula (1), wherein R 1 is tar, halo tar, cyclogaul, cyclogaul substitute, alcoxi, alcoxalcoxi, alcoxicarbone, alcoxalquilo, carboxi, carboxualquilo, halogeoquilo, haloalcoxi, haloalcoxi, cyclogaul, cycloalcoxi substitute Substitution, oxy, arilo, arilo substitution, isocyclopentyl, isocyclopentyl, isocyclopentadiol, isocyclopentadiol substitution, isocyclopropanediol, isocyclopentadiol substitution, isocyclopentadiol substitution, heteromorphic, heteromorphicSubstituted aminobenzene, aminobenzene or aminobenzene, such cyclopentyl substitute, cyclomethoxy substitute, cyclomethoxy substitute, arilo substitute, isocyclopropyl substitute, isocyclopropyl substitute The substituted non cyclopropane and isopropyl propylene are replaced by one to three independent substitutes, including hydroxyl, oxo, halogen, hydrocarbon, cyclopropyl, halo, tar, cyclopropyl clalquilo, alkylacrylonitrile, hydroxyl, compound butanediene, compound butadienyl, compound butadienyl, compound butadienyl, allylpropylpropylpropionylalkoxy and alkoxyalkyl and said substituted amino and substituted aminocarbonyl are substituted on the nitrogen atom by one or two substituents independently selected from alkyl, cycloalkyl, haloalkyl, alkylcycloalkyl, cycloalkylalkyl, alkylcycloalkylalkyl, hydroxyalkyl and alkoxyalkyl; R² is -COOH, tetrazol-5-yl, [1,3,4] oxadiazol-2-on-5-yl, [1,3,4] oxadiazol-2-thion-5-yl, [1,2, 4] oxadiazol-5-on-3-yl, [1,2,4] oxadiazol-5-thion-3-yl, [1,2,3,5] oxathiadiazol-2-oxide-4-yl, [1 , 2,4] thiadiazol-5-on-3-yl, isoxazol-3-ol-5-yl, 5-alkylisoxazol-3-ol-4-yl, 5-cycloalkylisoxazol-3-ol-4-yl, furazan -3-ol-4-yl, 5-alkylsulfonylamino- [1,3,4] oxadiazol-2-yl,Four, four four four four, four four four four four four four four four four four four four, four four four four four four, on-1-ilo, tetrazol-5-il-carbamoilo, tetrazol-5-carbonilo, [1, 2, 4] oxadiazolina-3, 1-1-1-1
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