QUANCARD, Jean,SIMIC, Oliver,PISSOT SOLDERMANN, Carole,TINTELNOT-BLOMLEY, Marina,SCHLAPBACH, Achim,ZOLLER, Thomas
申请号：
CR20160548
公开号：
CR20160548A
申请日:
2015.05.27
申请国别(地区):
CR
年份:
2017
代理人:
摘要：
The invention describes a new derivative of pyridinopyridine in formula or a pharmaceutically acceptable salt； (1) in this case, R1 is halogen, cyanogen or C1-C3 tar, which can be optionally replaced by halogen； R2 is C1-C6 tar, which can be selectively replaced by C1-C6 tar, alqueniloc2-c6, hydroxy once or more, N. N-di-let C1-C6, n-mono-let C1-C6, o-rg, RG, phenyl,or by C1-C6 alkoxy wherein said alkoxy may optionally again be substituted by C1-C6, N, N-di-C1-C6 alkylamino, Rg or phenyl； C3-C6 cycloalkyl optionally substituted by C1-C6 alkyl, N, N-di-C1-C6 alkylamino or C1-C6 alkoxy-C1-C6 alkyl, and / or two such optional substituents together with the atoms to which they are attached they can form a 4-6 membered saturated or spirocyclic null heterocyclic ring comprising 1-20 atoms； phenyl optionally substituted by C1-C6 alkoxy； a 5-6 membered heteroaryl ring having 1 to 3 heteroatoms selected from N and O,The ring can be replaced by C1-C6 tar, which can be replaced by amino group or hydroxyl group； RG； or N, n-di-rental carbon C1-C6； R is phenyl, which can be replaced by RA or 2-piridilo twice or more independently, and Rb once or more independently. It usually interacts with protein and / or self-protection activities in Malta, especially the interaction that may hinder such activities. Therefore, the third type of pyridine (pyridine) substance is replaced by RC once or more independently, or the fourth type of pyridine (pyridine) substance is replaced independently. The invention also describes the synthesis of these new pyrazolpyridin derivatives,Use as a drug, especially through interaction with Maltese proteins and / or self-protection activities.La presente invención describe nuevos derivados de la pirazolo-pirimidina de la fórmula (I) o una sal farmacéuticamente aceptable del mismo； (I) en la que, R1 es halógeno, ciano, o alquilo C1-C3 opcionalmente sustituido por halógeno； R2 es alquilo C1-C6 opcionalmente sustituido una o más veces por alquilo C1-C6, alqu
