N- (AMINOHETEROARYL) -1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

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专利权人:

SANOFI AVENTIS

发明人:

DUBOIS, LAURENT,EVANNO, YANNICK,MALANDA, ANDRE

申请号：

MYPI 20090316

公开号：

MY147465A

申请日:

2007.07.20

申请国别(地区):

MY

年份:

2012

代理人:

摘要：

THE INVENTION RELATES TO COMPOUNDS OF GENERAL FORMULA (1):IN WHICH X1 IS A HYDROGEN OR HALOGEN ATOM OR A (C1-C6)-ALKYL, (C3-C7)-CYCLOALKYL, (C3- C7)-CYCLOALKYL-(C1-C3)-ALKYLENE, (C1-C6)-FLUOROALKYL, CYANO, C(O)NR1R2, NITRO, (C1-C6)- THIOALKYL, -S(O)-(C1 -C6)-ALKYL, -S(0)2-(C1-C6)-ALKYL, S02NR1R2, ARYL-(C1-C6)-ALKYLENE, ARYL OR HETEROARYL GROUP, THE ARYL AND THE HETEROARYL BEING OPTIONALLY SUBSTITUTED； X2 IS A HYDROGEN OR HALOGEN ATOM OR A (C1-C6)-ALKYL, (C3-C7)-CYCLOALKYL, (C3-C7)-CYCLOALKYL-(C1- C3)-ALKYLENE, (C1-C6)-FLUOROALKYL,(C1-C6)-ALKOXYL,(C3-C7)-CYCLOALKYL-(C1-C6)-ALKYLENE- O-, (C1-C6)-FLUOROALKOXYL, CYANO, C(O)NR1R2, (C1-C6)-THIOALKYL, -S(O)-(C1-C6)-ALKYL, -S(O)2-(C1-C6)-ALKYL, SO2NRIR2, ARYL-(C1-C6)-ALKYLENE, ARYL OR HETEROARYL GROUP, THE ARYL AND THE HETEROARYL BEING OPTIONALLY SUBSTITUTED； X3 AND X4 ARE, INDEPENDENTLY OF ONE ANOTHER, A HYDROGEN OR HALOGEN ATOM OR A (C1-C6)-ALKYL, (C3-C7)-CYCLOALKYL, (C3-C7)- CYCLOALKYL-(C1-C3)-ALKYLENE, (C1-C6)-FLUOROALKYL, (C1-C6)-ALKOXYL, (C3-C7)-CYCLOALKYL- (C1-C6)-ALKYLENE -O-, (C1-C6)-FLUOROALKOXYL, CYANO, C(O)NR1R2, NITRO, NR1R2, (C1-C6)- THIOALKYL, -S(O)-(C1-C6)-ALKYL, -S(O)2-(C1-C6)-ALKYL, SO2NR1R2, NR3COR4, NR3SO2R5, ARYL-(C1-C6)-ALKYLENE, ARYL OR HETEROARYL GROUP, THE ARYL AND THE HETEROARYL BEING OPTIONALLY SUBSTITUTED； Z1, Z2, Z3 AND Z4 ARE, INDEPENDENTLY OF ONE ANOTHER, A NITROGEN ATOM OR A C(R6) GROUP； N IS EQUAL TO 0, 1, 2 OR 3； Y IS AN OPTIONALLY SUBSTITUTED ARYL OR HETEROARYL； RA AND RB ARE, INDEPENDENTLY OF ONE ANOTHER, A HYDROGEN ATOM OR A (C 1 -C6).

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