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Derivatives of pyrrolopyridin-2-carboxamides, their preparation and their application in therapeutics
专利权人:
SANOFI
发明人:
DUBOIS, LAURENT,EVANNO, YANNICK,MALANDA, ANDRE
申请号:
ES08761773
公开号:
ES2384289T3
申请日:
2008.01.17
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compound that responds to formula (I) n is equal to 0, 1, 2 or 3; the pyrrolopyridine core is a pyrrolo [3,2-b] pyridine group, a pyrrolo [3,2-c] pyridine group, a pyrrolo [2,3-5c] pyridine group or a pyrrolo [2,3-b] pyridine group, the pyrrolopyridine core being optionally substituted on the carbons of the 4, 5, 6 and / or 7 position by one substituent ovaries X, identical or different from each other, chosen from a halogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C6 alkylene, C1-C6 fluoroalkyl, C1-C6 alkoxy, C3-cycloalkoxyl group C7, C3-C7 cycloalkyl-C1-C6-O- alkylene, C1-C6 fluoroalkoxy, cyano, C (O) NR1R2, nitro, NR1R2, C1-C6 thioalkyl, -S (O) -10 C1-C6 alkyl, -S (O) 2-C 1 -C 6 alkyl, SO 2 NR 1 R 2, NR 3 COR 4, NR 3 SO 2 R 5, aryl, aryl-C 1 -C 5 alkylene, heteroaryl or C 1 -C 5 alkylene, aryl or heteroaryl, the aryl or heteroaryl being optionally substituted by one of the substituted ovaries between a halogen, an alkyl group C1-C6, C3-C7 cycloalkyl, C3-C7-alkylene-O-1-C3 cycloalkyl, C1-C6 fluoroalkyl, C1-C6 alkoxy, C3-C7 cycloalkoxy, C3-C7-O-C1-C3 alkylene, fluoroalkoxyl C1-C6, nitro or cyano; 15Y represents a heteroaryl optionally substituted by one or more groups selected from a halogen atom or a C1-C6 alkyl group, C3-C7 cycloalkyl, C3-C7-alkylene-C1-C3 cycloalkyl, C1 fluoroalkyl -C6, hydroxyl, C1-C6 alkoxy, C3-C7 cycloalkoxy, C3-C7-cycloalkyl-O-C1-C6, C1-C6 fluoroalkoxy, cyano, C (O) NR1R2, nitro, NR1R2, C1-C6 thioalkyl, thiofluoro C1-C6 alkyl, thiol, -S (O) -C1-C6 alkyl, -S (O) -C3-C7-S (O) -cycloalkyl-C1-C6-cycloalkyl-C3-C7, -S (O) 2-C1-C6 alkyl, -S (O) 2-C3-C7 cycloalkyl, -S (O) 2 alkylene -C1-C6-20cycloalkyl-C3-C7- SO2NR1R2, NR3COR4, NR3SO2R5, aryl, aryl-C1-alkylene C5, heteroaryl or heteroaryl-C1-C5 alkylene, the aryl or heteroaryl being optionally substituted by one or more substituents selected from one h halogen, a C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7-alkylene-C1-C3 cycloalkyl, C1-C6 fluoroalkyl, C1-C6 alkoxy, C3-C7 cycloalkoxy, C3
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