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N-(胺基-雜芳基)-1H-吲哚-2-甲醯胺衍生物,其製備及其治療用途
专利权人:
SANOFI-AVENTIS
发明人:
DUBOIS, LAURENT,劳伦特 杜波斯,勞倫特 杜波斯,EVANNO, YANNICK,亚尼克 艾维侬,亞尼克 艾維儂,MALANDA, ANDRE,安德瑞 玛兰达,安德瑞 瑪蘭達,劳伦特 杜波斯,勞倫特 杜波斯,亚尼克 艾维侬,亞尼克 艾維儂,安德瑞 玛兰达,安德瑞 瑪蘭達
申请号:
TW096126382
公开号:
TWI388554B
申请日:
2007.07.19
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
The invention relates to compounds of general formula (I):in which X1represents a hydrogen or halogen atom or a group C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, cyano, C(O)NR1R2, nitro, C1-C6-thioalkyl, -S(O)-C1-C6-alkyl, -S(O)2-C1-C6-alkyl, SO2NR1R2, aryl-C1-C6-alkylene, aryl or heteroaryl, the aryl and the heteroaryl being optionally substituted; X2represents a hydrogen or halogen atom or a group C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C3-C7-cycloalkyl-C1-C6-alkylene-O-, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, C1-C6-thioalkyl, -S(O)-C1-C6-alkyl, -S(O)2-C1-C6-alkyl, SO2NR1R2, aryl-C1-C6-alkylene, aryl or heteroaryl, the aryl and the heteroaryl being optionally substituted; X3and X4represent, independently of each other, a hydrogen or halogen atom or a group C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C3-C7-cycloalkyl-C1-C6-alkylene-O-, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, -S(O)-C1-C6-alkyl, -S(O)2-C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-C1-C6-alkylene, aryl or heteroaryl, the aryl and the heteroaryl being optionally substituted; Z1, Z2, Z3and Z4represent, independently of each other, a nitrogen atom or agroup C(R6); n is equal to 0, 1, 2 or 3; Y represents an optionally substituted aryl or heteroaryl; Ra and Rb represent, independently of each other, a hydrogen atom or a group C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, hydroxyl, C1-C6-alkoxyl, C3-C7-cycloalkyl-C1-C6-alkylene-O-, C1-C6-fluoroalkoxyl, aryl or heteroaryl, Ra and Rb possibly being substituted; in the form of base or of acid-addition s
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