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АДЪЮВАНТЫ-РАЗБАВИТЕЛИ ДЛЯ ЖИВЫХ ВАКЦИН ОТ БОЛЕЗНЕЙ СВИНЕЙ
专利权人:
СОСЬЕТЕ ДЭКСПЛУАТАСЬОН ДЕ ПРОДЮИ ПУР ЛЕ ЭНДЮСТРИ ШИМИК СЕППИК (FR)
发明人:
БЕРТРАН Франсуа (FR),ДЕВИЛЛЬ Себастьен (FR),ДЮПЮИ Лоран (FR)
申请号:
RU2012145084/15
公开号:
RU2012145084A
申请日:
2011.03.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A process for preparing graft injectable composition for combating reproductive and respiratory syndrome pigs (PRRS), comprising at least steps of: a) mixing the live vaccine prepared for immediate administration with adjuvant diluent (AD), wherein that said adjuvant diluent is an emulsion of "oil in water" or microemulsion type "oil in water" or an aqueous solution containing water and at least one inorganic salt selected from aluminum hydroxide, cerium nitrate , Zinc sulfate, colloid of iron hydroxide or calcium chloride, salts of divalent or trivalent metal or sympathomimetic soedineniy.2. A method according to claim 1, characterized in that the adjuvant, diluent (AD) comprises an adjuvant, the aqueous phase and, optionally, a polymer family natriya.3 polyacrylates. Method according to one of the preceding claims, characterized in that the virus contained in said live vaccine is lyophilized before step a) .4. A method according to claim 1 or 2, characterized in that the said adjuvant is an emulsion-diluent type "oil in water", containing 100% of its mass: - from 99 to 50 wt%. water, in particular from 99 to 75% by weight. water, and even more particularly from 90 to 80% by weight. water - 1 to 50% by weight. oil adjuvant, in particular from 1 to 25% by weight. oil adjuvant, and even more particularly from 5 to 19% by weight. adyuvanta.5 oil. A method according to claim 3, characterized in that the said adjuvant is an emulsion-diluent type "oil in water", containing 100% of its mass: - from 99 to 50 wt%. water, in particular from 99 to 75% by weight. water, and even more particularly from 90 to 80% by weight. water - 1 to 50% by weight. oil adjuvant, in hours1. Способ получения пригодной для инъекций прививочной композиции, предназначенной для борьбы с репродуктивно-респираторным синдромом свиней (PRRS), включающий по меньшей мере этап:а) смешение живой вакцины, приготовленной для немедленного введения, с адъювантом-разбавителем (AD),отличающийся тем, что указа
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