Henry Bernard LOWMAN,Luc Roland Desnoyers,Shouchun Liu
申请号:
US16712422
公开号:
US20200270350A1
申请日:
2019.12.12
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The invention relates generally to variant activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these variant anti-EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.