Henry Bernard LOWMAN,Luc Roland DESNOYERS,Shouchun LIU,James William WEST,Jason Gary SAGERT,Olga VASILJEVA,Elizabeth-Edna Mary MENENDEZ
申请号:
US15875947
公开号:
US20180333507A1
申请日:
2018.01.19
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these anti-EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.