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Pyrazole derivatives and their use as antagonists of LPAR5
专利权人:
SANOFI
发明人:
NAZARE, Marc,KOZIAN, Detlef,EVERS, Andreas,CZECHTIZKY, Werngard
申请号:
ES13723151
公开号:
ES2612205T3
申请日:
2013.05.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of the formula I, ** Formula ** in which R1 is selected from the series consisting of hydrogen, (C1-C6) alkyl, cycloalkyl (C3-C7), cycloalkyl (C3-C7) - alkyl (C1 -C4) -, Ar and Ar-alkyl (C1-C4) -; R2 and R3 are independently selected from each other in the series consisting of hydrogen, halogen, (C1-C4) alkyl, cycloalkyl (C3-C7), cycloalkyl (C3-C7) -alkyl (C1-C4) -, Ar, Ar-(C1-C4) alkyl -, (C1-10 C4) alkyl -O-, cycloalkyl (C3-C7) -O-, cycloalkyl (C3-C7) -alkyl (C1-C4) -O-, Ar- O- and Ar-C1-C4 alkyl-O-, R4 and R5 are independently selected from each other in the series consisting of hydrogen, fluorine and (C1-C6) alkyl, or the groups R4 and R5 together with the The carbon atom that supports them forms a cycloalkane (C3-C7) ring that is not substituted or substituted with one or more identical or different substituents selected from the series consisting of fluorine and (C1-C4) alkyl; R11, R12, R13 and R14 are independently selected from each other in the series consisting of hydrogen and (C1-C4) alkyl; Ar is selected from the series consisting of phenyl, naphthyl and a 5-membered or 6-membered aromatic monocyclic heterocycle comprising one or two identical or different ring heteroatoms selected from the series consisting of N, O and S, which are all not substituted or substituted with one or more identical or different substituents selected from the series consisting of halogen, (C1-C4) alkyl, cycloalkyl (C3-C7), cycloalkyl (C3-C7) -alkyl (C1-C4) -, cyano and (C1-C4) alkyl -O-; V is selected from the series consisting of R12-N (R13) -, and in this case G and M are not present, or V is selected from the series consisting of -N (R14) -, -N (R14) -alkyl (C1-C4) -, -O- and -O-alkyl (C1-C4) -, and in this case G is selected from the series consisting of a direct bond and phenylene which is not substituted or substituted with one or more identical or different substituents selected from the series consisting of halogen, (C1-C4) alkyl, cyano and (C1-C4) alkyl -O-
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