RUF, Sven,PERNERSTORFER, Josef,SADOWSKI, Thorsten,HORSTICK, Georg,SCHREUDER, Herman,BUNING, Christian,WIRTH, Klaus
申请号：
ES12738473
公开号：
ES2560381T3
申请日:
2012.07.25
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any relationship, or a physiologically acceptable salt thereof, or a physiologically acceptable solvate of any of them, in which Ht is chosen from the series that consists of G is R71-OC (O) -； R1 is selected from the series consisting of hydrogen, halogen, (C1-C6) alkyl, CF3, cycloalkyl (C3-C7) -CsH2s-, Ar- CsH2s-, Ar-O, (C1-C6) alkyl -O- , (C1-C6) alkyl -S (O) m- and NC-； in which s is an integer chosen from the series consisting of 0, 1, 2 and 3； R2 is selected from the series consisting of hydrogen, halogen, (C1-C6) alkyl, CF3, (C1-C6) alkyl -O-, (C1-C6) alkyl-S (O) m- and NC-； R10 is chosen from the series consisting of R11； R11 is Ar； R30 is chosen from the series consisting of cycloalkyl (C3-C7) and R32-CuH2u-, in which u is an integer chosen from the series consisting of 0, 1, 2 and 3； R32 is chosen from the series consisting of phenyl and a 5-membered or 6-membered monocyclic aromatic heterocycle comprising one, two or three identical or different annular heteroatoms chosen from the series consisting of nitrogen, oxygen and sulfur and are linked via a annular carbon atom, in which the phenyl and heterocycle are all optionally substituted with one or more identical or different substituents chosen from the series consisting of halogen, (C1-C6) alkyl, cycloalkyl (C3-C7), HO- , (C1-C6) alkyl -O-, -O-CH2-O-, -O-CF2-O-, (C1-C6) alkyl -S (O) m-, H2N-S (O) 2-, (C1-C4) alkyl -NH-S (O) 2-, di ((C1-C4) alkyl) NS (O) 2-, H2N-, (C1-C6) alkyl -NH-, di (C1 (alkyl) - C6)) N-, (C1-C4) alkyl -C (O) -NH-, (C1-C4) alkyl -S (O) 2-NH- and NC-； R40 is chosen from the series consisting of hydrogen and (C1-C4) alkyl； R50 is chosen from the series consisting of hydrogen, (C1-C6) alkyl, HO- and (C1-C6) alkyl -O-； R60 is chosen from the series consisting of hydrogen and (C1-C6) alkyl； R71 is hydrogen； Ar, regardless of each of the other Ar groups, is selected from the series consisting
