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Aminoester derivatives
专利权人:
Chiesi Farmaceutici S.p.A.
发明人:
ARMANI, Elisabetta,AMARI, Gabriele,CAPALDI, Carmelida,BLACKABY, Wesley,LINNEY, Ian,VAN DE PÖEL, Hervé,BAKER-GLENN, Charles,TRIVEDI, Naimisha
申请号:
ES15731261
公开号:
ES2688826T3
申请日:
2015.06.03
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of general formula (I) ** Formula ** in which each R1 is hydrogen or is independently selected from the group consisting of: halogen, (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-) alkyl C4), hydroxyl, -SO2NRIRII, -CN, -NRISO2RIII, -NRIRII, - (CO) NRIRII and -NRI (CO) RIII, and in which said (C1-C4) alkyl is optionally substituted with one or more selected groups between cycloalkyl (C3-C7), hydroxyl and -NRIRII and wherein said (C1-C4) alkoxy is optionally substituted with one or more halogens or cycloalkyl (C3-C7) groups in which, RI is hydrogen or (C1 -C6); RII is hydrogen or (C1-C6) alkyl; RIII is hydrogen or (C1-C6) alkyl; n is an integer that varies from 1 to 3; each R2 is hydrogen or is independently selected from the group consisting of: halogen, (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkyl, hydroxy, -SO2NRIRII, -CN, -NRISO2RIII, - NRIRII, - (CO) NRIRII and -NRI (CO) RIII and wherein said (C1-C4) alkyl is optionally substituted with one or more groups selected from cycloalkyl (C3-C7) or, hydroxyl and -NRIRII and in the that said (C1-C4) alkoxy is optionally substituted with one or more halogens or cycloalkyl (C3-C7) groups in which, RI is hydrogen or (C1-C6) alkyl; RII is hydrogen or (C1-C6) alkyl; RIII is hydrogen or (C1-C6) alkyl; m is an integer that varies from 1 to 3; R3 and R4 are different or the same and are independently selected from the group consisting of: H, cycloalkylcarbonyl (C3-C7), alkyl (C1-C6) optionally substituted with one or more substituents selected from cycloalkyl (C3-C7) and cycloalkenyl ( C5-C7), haloalkyl (C1-C6), cycloalkyl (C3-C7), cycloalkenyl (C5-C7), alkenyl (C2-C6) and alkynyl (C2-C6); or R3 and R4, together with the interconnecting atoms, form a 2,2-difluoro-1,3-dioxolane ring of formula (r) fused to the phenyl structural unit that carries -OR3 and -OR4 groups, where asterisks indicate carbon atoms shared with said phenyl ring: ** Formula ** each R5 is selected from the group consisting of: CN, NO2, CF3 and haloge
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