CHARLES BAKER-GLENN,CARMELIDA CAPALDI,GABRIELE AMARI,ELISABETTA ARMANI
申请号：
ARP150101771
公开号：
AR100731A1
申请日:
2015.06.04
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
The present relates to compounds which are inhibitors of the Enzyme phosphodiesterase 4 (PDE4) while m3 Muscarinic Receptor Antagonists, Methods for preparing such Compounds, compositions containing them.Claim 1: wherein is a compound of General formula {1} where each r u00b9 is independently Hydrogen or selected from the group consisting of: c u2081 u208b u2084 Halogen, alkyl, alkoxy c u2081 u208b u2084, c u2081 u208b u2084 haloalquilo, so u2082nririi hydroxy -, - CN, - N (RI) so u2082riii, Nririi -, - C (o) - N (nririi and RI RIII) C (o),And where this c u2081 u208b u2084 alkyl is optionally substituted with one or more selected from c u2083 u208b u2087 cycloalkyl Hydroxy groups, and nririi - and where this is c u2081 u208b u2084 alkoxy optionally substituted with one or more halogens or cycloalkyl groups c u2083 u208b u2087 whereRI is Hydrogen or alkyl c u2081 u208b u2086； Hydrogen or alkyl c u2081 u208b u2086 RII RIII is c u2081 u208b u2086； Hydrogen or alkyl； n is an integer in the range 1 to 3； and each R u00b2 r u00b3 are different or equal and selected independently from the group consisting of hydrogen, halogen, c u2081 u208b By Land. C u2081 u208b u2084 alkyl, Hydroxy, alkoxy, c u2081 u208b u2084 haloalquilo, so u2082nririi -, - CN, - N - (RI) so u2082riii, nririi,Nririi and - C (o) - N (RI) C (o) and the c u2081 u208b u2084 RIII where alkyl is optionally substituted with one or more selected from c u2083 u208b u2087 cycloalkyl Hydroxy groups, and nririi - and where this is c u2081 u208b u2084 alkoxy optionally substituted with one or more halogens or cycloalkyl groups c u2083 u208b u2087 OJ Where,RI is Hydrogen or alkyl c u2081 u208b u2086； Hydrogen or alkyl c u2081 u208b u2086 RII RIII is c u2081 u208b u2086； Hydrogen or alkyl, M and M are different or similar and are an integer in the range 1 to 3； and r u2074 r u2075 are different or equal and selected independently from the group consisting of h； C u2083 u208b u2087 cicloalquilcarbonilo c u2081 u208b
