NAZARE Mark (DE),НАЗАРЕ Марк (DE),KOTSIAN Detlef (DE),КОЦИАН Детлеф (DE),BOSSART Martin (DE),БОССАРТ Мартин (DE),CHEKHTIZKIJ Verngard (DE),ЧЕХТИЗКИЙ Вернгард (DE),EFERS Andreas (DE),ЭФЕРС Андреас (DE),NAZARE Mark,НАЗАРЕ Марк,KOTSIAN Detlef,КОЦИАН Детлеф,BOSSART Martin,БОССАРТ Мартин,CHEKHTIZKIJ Verngard,ЧЕХТИЗКИЙ Вернгард,EFERS Andreas,ЭФЕРС Андреас
申请号：
RU2014151240
公开号：
RU0002647727C2
申请日:
2013.05.16
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula (I), wherein A is selected from group consisting of R11-O-C(O)- and Het1； R1, R2, R3 and R4, independently of one another, are selected from the group consisting of hydrogen, halogen, (C1-C4) alkyl, Ar- (C1-C4) alkyl-, Ar, Het2, Ar-C(O)-, R14-N(R15)-C(O)-, (C1-C4)alkyl-O-, Ar-O-, Ar-(C1-C4)alkyl-O-, Het3-S(O)2-, (C1-C4)alkyl-NH- and di((C1-C4) alkyl)N-y or R1 and R2, or R2 and R3, or R3 and R4, together with the carbon atoms to which they are attached, can form a carbocyclic ring which is selected from the group consisting of benzene and a 5- to 7-membered cycloalkane, wherein the benzene ring is unsubstituted or substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C4) alkyl and (C1-C4) alkyl-O-, and cycloalkane ring is unsubstituted or substituted by one or more identical or different substituents selected from the group consisting of fluorine and (C1-C4) alkyl； R5 is selected from the group consisting of hydrogen and (C1-C4) alkyl； R11, R12, R14 and R15, each independently of one another, is selected from the group consisting of hydrogen and (C1-C4) alkyl； one of the Z1 and Z2 groups is (C3-C8) cycloalkyl, and the other is selected from the group consisting of hydrogen, (C1-C8) alkyl, (C3-C8) cycloalkyl and phenyl, wherein all cycloalkyl groups, independently of one another, are unsubstituted or substituted by one or more identical or different substituents selected from the group consisting of fluorine and (C1-C4) alkyl, and phenyl group is unsubstituted or substituted by one or more identical or different substituents selected from the group consisting of halogen and (C1-C4) alkyl； Ar represents a phenyl or aromatic 5-membered or 6-membered monocyclic heterocycle that contains in the ring one or two identical or different heteroatoms selected from the group consisting of N, O, and S atoms, and wherein phenyl is unsubstituted or subst
