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SUBSTITUTED DERIVATIVES OF 3-HETEROAROYLAMINOPROPIONIC ACID AND THEIR APPLICATION AS DRUGS
专利权人:
SANOFI
发明人:
RUF Sven (DE),РУФ Свен (DE),SADOVSKI Torsten (DE),САДОВСКИ Торстен (DE),VIRT Klaus (DE),ВИРТ Клаус (DE),SHROJDER Kherman (DE),ШРОЙДЕР Херман (DE),BUNING Kristian (DE),БУНИНГ Кристиан (DE),RUF Sven,РУФ Свен,SADOVSKI Torsten,САДОВСКИ Торстен,VIRT Klaus,ВИРТ Клаус,SHROJDER Kherman,ШРОЙДЕР Херман,BUNING Kristian,БУНИНГ Кристиан
申请号:
RU2013139349
公开号:
RU0002632897C2
申请日:
2012.01.26
申请国别(地区):
RU
年份:
2017
代理人:
摘要:
FIELD: pharmacology.SUBSTANCE: invention relates to a compound of formula Iin any of its stereoisomeric forms or a physiologically acceptable salt thereof, wherein A is selected from the group consisting of C(R1) and N; D is selected from the group consisting of C(R2) and N; E is selected from the group consisting of C(R3) and N; L is selected from the group consisting of C(R4); where at least one and not more than two of A, D, E or L is N; G is selected from the group consisting of R71-O-C(O)-;R1 is selected from the group consisting of hydrogen, halogen; R2 is selected from the group consisting of hydrogen, halogen, (C1-C7)-alkyl, Het2 and Ar-CsH2s-, where s is 0; R3 is selected from the group consisting of hydrogen, Het2, R11-O-; R4 and R10 are selected from the group consisting of hydrogen, halogen; provided that one of the R2, R3 is a cyclic substituent; R11 is selected from the group consisting of hydrogen, R14; R12 and R13 are hydrogen; R14 is (C1-C10)-alkyl optionally substituted by one substituent, which is an oxo group; R30 is selected from the group consisting of R31, R32-CuH2u-, where u is 0; R31 is (C1-C10)-alkyl; R32 is phenyl, wherein phenyl is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C6)-alkyl, (C1-C6)-alkyl-O-, CF3-; R40, R50, R60 and R71 are hydrogen; Ar, independently of other Ar groups, is selected from the group consisting of phenyl and aromatic 5-membered or 6-membered monocyclic heterocycle which includes one, two or three identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and is bonded through the carbon atom of the ring, wherein phenyl and heterocycle are optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C6)-alkyl, HO-(C1-C6)-alkyl, Het4, (C1-C6)-alkyl-O-, -CF3, -CO-(C1-C6)-alkyl, -CO-NR12R13 and NC-; and wherein phenyl can be sub
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