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Alkynylpyrimidines as Tie2 kinase inhibitors
专利权人:
Bayer Intellectual Property GmbH
发明人:
HARTUNG, Ingo,BOTHE, Ulrich,KETTSCHAU, Georg,LUECKING, Ulrich,MENGEL, Anne,KRUEGER, Martin,THIERAUCH, Karl-Heinz,LIENAU, Philip,BOEMER, Ulf
申请号:
ES08773692
公开号:
ES2554160T3
申请日:
2008.06.19
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of general formula (I): ** Formula ** in which: R1 is selected from the group consisting of hydrogen, halogen, nitro, cyano, -C1-C6 alkyl, -C1-C6-thio alkyl, - C1-C6 haloalkyl, C3-C10 cycloalkyl, - (CH2) mORc, - (CH2) mNRd1Rd2, and - (CH2) mC (O) Rb; R2 represents hydrogen, -C (O) Rb, -S (O) 2Rb, -P (O) (ORf) 2, or -S (O) 2- (CH2) 2-Si (RhRkRl), or is selected from group consisting of -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -C3-C10 cycloalkyl, aryl, heteroaryl and -C3-C10 heterocycloalkyl, wherein said moieties are not substituted or substituted one or more times, independently of each other, with halogen, nitro, cyano, -C1-C6 alkyl, aryl, heteroaryl, -ORc, -NRd1Rd2, -C1-C6 haloalkyl, -C (O) Rb, or -S (O) 2Rb; R3 is selected from the group consisting of -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, aryl, heteroaryl and -C3-C10 cycloalkyl, wherein said moieties are unsubstituted or substituted one or more times, independently of one another, with halogen, nitro, cyano, -C1-C6 alkyl, aryl, heteroaryl, -ORc, - NRd1Rd2, -haloalkyl of C1-C6, -C (O) Rb, or -S (O) 2Rb; R4 is selected from the group consisting of hydrogen, -OR7, -SR7 and -NR7R8; R5 is selected from the group consisting of hydrogen, halogen, nitro, cyano, -C1-C6 alkyl, -C3-C10 cycloalkyl, -C1-C6 haloalkyl, -C1-C6-thio alkyl, - (CH2) nORf , - (CH2) nNRsC (O) Rm, - (CH2) nNRsS (O) 2Rm, - (CH2) nNRg1Rg2, - (CH2) nC (O) Rn, and - (CH) 2) nS (O) 2Rn; R6 is selected from the group consisting of hydrogen, halogen, nitro, cyano, hydroxyl, -C1-C6 alkyl, - C3-C10 cycloalkyl, -C1-C6 haloalkyl, -C1-C6 haloalkoxy, -C1 -alkoxy -C6, and -C1-C6-thio alkyl; R7, R8 independently of each other, are selected from the group consisting of hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -C3-C10 cycloalkyl, - (CH2) p- aryl, - (CH2) p-heteroaryl and - C3-C10 heterocycloalkyl, wherein said moieties are unsubstituted or substituted one or more times, independently of one another, with halogen, nitro, cyano, -C
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