HARTUNG, INGO,INCE, STUART,KETTSCHAU, GEORG,THIERAUCH, KARL-HEINZ,BRIEM, HANS,SCHWEDE, WOLFGANG,TER LAAK, ANTONIUS M.
申请号：
ES07764751
公开号：
ES2467017T3
申请日:
2007.06.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of general formula (I): ** Formula ** in which: R1 represents -C (O) Rb or is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2- alkynyl C6, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, wherein said moieties are unsubstituted or substituted one or more times, independently of one another, with R6； R2 represents a C3-C10 cycloalkyl optionally substituted with R7； R3 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, hydroxy, amino, halogen, cyano； R4, R5, R6, R7, R8 independently from each other, are selected from the group consisting of hydrogen, C1-C6 alkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, C1-C6 haloalkyl, C1- haloalkoxy C6, aryl, heteroaryl, hydroxy, amino, halogen, cyano, nitro, -C (O) Rb, -S (O) 2Rb, -ORc, -NRd1Rd2, -OP (O) (ORc) 2, in which alkyl of C1-C6, C3-C10 heterocycloalkyl and C3-C10 cycloalkyl of R4, R5, R6 and R7, are optionally substituted one or more times with R8, and wherein C1-C6 alkyl, C3-C10 heterocycloalkyl and C3-C10 cycloalkyl of R8, are optionally substituted once with R8； Ra is selected from the group consisting of hydrogen or C1-C6 alkyl； Rb is selected from the group consisting of hydroxyl, -ORc, -SRc, -NRd1Rd2, aryl and C1-C6 alkyl.Un compuesto de fórmula general (I):**Fórmula** en la que: R1 representa -C(O)Rb o se selecciona del grupo que consiste en alquilo de C1-C6, alquenilo de C2-C6, alquinilo de C2-C6, cicloalquilo de C3-C10, heterocicloalquilo de C3-C10, en el que dichos restos están no sustituidos o sustituidos una o más veces, independientemente entre sí, con R6； R2 representa un cicloalquilo de C3-C10 opcionalmente sustituido con R7； R3 se selecciona del grupo que consiste en hidrógeno, alquilo de C1-C6, alcoxi de C1-C6, haloalquilo de C1-C6, haloalcoxi de C1-C6, hidroxi, amino, halógeno, ciano； R4, R5, R6, R7, R8 independientemente entre sí, se seleccionan del grupo que consiste en hidrógeno, alquilo de C1-C6, cicloalquilo d
