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6-Amino-pyridazin-3-yl-carboxamide compounds substituted as protein kinase modulators
专利权人:
Xcovery Holding Company LLC
发明人:
LIANG, Congxin
申请号:
ES11831702
公开号:
ES2610226T3
申请日:
2011.10.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula III: ** Formula ** or a salt thereof; or a hydrate, solvate, or polymorph thereof; in which: n is 0-2; R5 and R11 are each independently H, alkyl or Z1; R9 is alkyl; R10 is H, alkyl or Z1; Each Z1 is independently halogen, CN, NO2, OR15, SR15, S (o) 2OR15, NR15R16, perfluoroalkyl C1-C2, perfluoroalkoxy C1-C2, 1,2-methylenedioxy, C (O) OR15, C (O) NR15R16, OC (O) NR15R16, NR15C (O) NR15R16, C (NR16) NR15R16, NR15C (NR16) NR15R16, S (O) 2NR15R16, R17, C (O) R17, NR15C (O) R17, S (O) R17, S (O) 2R17, R16, oxo, C (O) R16, C (O) (CH2) mOH, (CH2) mOR15, (CH2) mC (O) NR15R16, NR15S (O) 2R17, where each m is independently 0-6; each R15 is independently hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl; each R16 is independently hydrogen, alkenyl, alkynyl, C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl; and each R17 is independently C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl.Un compuesto de fórmula III:**Fórmula** o una sal del mismo; o un hidrato, solvato, o polimorfo del mismo; en la que: n es 0-2; R5 y R11 son cada uno independientemente H, alquilo o Z1; R9 es alquilo; R10 es H, alquilo o Z1; cada Z1 es independientemente halógeno, CN, NO2, OR15, SR15, S(o)2OR15, NR15R16, perfluoroalquilo C1-C2, perfluoroalcoxi C1-C2, 1,2-metilendioxi, C(O)OR15, C(O)NR15R16, OC(O)NR15R16, NR15C(O)NR15R16, C(NR16)NR15R16, NR15C(NR16)NR15R16, S(O)2NR15R16, R17, C(O)R17, NR15C(O)R17, S(O)R17, S(O)2R17, R16, oxo, C(O)R16, C(O)(CH2)mOH, (CH2)mOR15, (CH2)mC(O)NR15R16, NR15S(O)2R17, donde cada m es independientemente 0-6; cada R15 es independientemente hidrógeno, alquilo C1-C4 o cicloalquilo C3-C6; cada R16 es independientemente hidrógeno, alquenilo, alquinilo, cicloalquilo C3-C6, arilo, heterociclilo, heteroarilo, alquilo C1-C4 o alquilo C1-C4 sustituido con cicloalquilo C3-C6, arilo,
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