A compound of general formula (I): ** Formula ** in which: R1 represents H or -C (O) Rb or is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, alkynyl of C2-C6, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, wherein said moieties are unsubstituted or substituted one or more times, independently of one another, with R6； R2 represents hydrogen, -NRd1Rd2, -C (O) Rb, or is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, C3 heterocycloalkyl- C10, aryl, heteroaryl, wherein said moieties are unsubstituted or individually or multiple substituted, independently of each other, with R7； R3 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, hydroxy, amino, halogen, cyano； R4, R5, R6, R7, R8, independently from each other, are selected from the group consisting of hydrogen, C1-C6 alkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, C1-C6 haloalkyl, C1 haloalkoxy -C6, aryl, heteroaryl, hydroxy, amino, halogen, cyano, nitro, -C (O) Rb, -S (O) 2Rb, -ORc, -NRd1Rd2, -OP (O) (ORc) 2, in which C1-C6 alkyl, C3-C10 heterocycloalkyl and C3-C10 cycloalkyl of R4, R5, R6 and R7 are optionally substituted one or more times, in the same way or differently, with R8, and in which alkyl C1-C6, C3-C10 heterocycloalkyl and C3-C10 cycloalkyl of R8 are optionally substituted once with R8； Ra is selected from the group consisting of hydrogen or C1-C6 alkyl； Rb is selected from the group consisting of hydroxyl, -ORc, -SRc, -NRd1Rd2, and C1-C6 alkyl； Rc is selected from the group consisting of hydrogen, -C (O) Rb, C1-C6 alkyl, C1-C6 haloalkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, wherein C1-C6 alkyl, C1-C6 haloalkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl are optionally substituted one or more times, in the same way or differently, with hydroxyl, halogen, aryl, or -NRd1Rd2, and in which alkyl C1-C6, C1-C6 haloalkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl are option
