WISHART, Neil,ARGIRIADI, Maria A.,CALDERWOOD, David J.,ERICSSON, Anna M.,FIAMENGO, Bryan A.,FRANK, Kristine E.,FRIEDMAN, Michael,GEORGE, Dawn M.,GOEDKEN, Eric R.,JOSEPHSOHN, Nathan S.,LI, Biqin C.,MOR
申请号：
ES09763424
公开号：
ES2559403T3
申请日:
2009.06.09
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I) ** Formula ** pharmaceutically acceptable salts thereof wherein T is N, U is N, X is CR3 and Y is N； or T is CR6, U is N, X is CR3 and Y is N； or T is N, U is CR4, X is CR3 and Y is N； or T is CR6, U is CR4, X is CR3 and Y is N； R1 and R2 are each independently hydrogen, deuterium, -N (Ra) (Rb), halogen, -ORa, -SRa, -S (O) Ra, -S (O) 2Ra, -NO2, -C (O) ORa, -CN, -C (O) N (Ra) (Rb), -N (Ra) C (O) (Rb), -C (O) Ra, -C (OH) RaRb, -N (Ra) S (O) 2-Rb, -S (O) 2N (Ra) (Rb), -CF3, -OCF3, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, C3 cycloalkyl -C10 optionally substituted, optionally substituted C1-C10 heteroaryl, optionally substituted C1-C10 heterocyclyl, or optionally substituted C6-C10 aryl； R5 is hydrogen, deuterium, -N (Ra) (Rb), halogen, -SRa, -S (O) Ra, -S (O) 2Ra, -NO2, -C (O) ORa, -CN, -C ( O) N (Ra) (Rb), -N (Ra) C (O) (Rb)； -C (O) Ra, -C (OH) RaRb, -N (Ra) S (O) 2-Rb, -S (O) 2N (Ra) (Rb), -CF3, -OCF3, C1-C6 alkyl optionally substituted, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C1-C10 heteroaryl, optionally substituted C1-C10 heterocyclyl, or optionally substituted C6-C10 aryl； wherein in a radical containing -N (Ra) (Rb), nitrogen, Ra and Rb can form a ring such that -N (Ra) (Rb) represents optionally substituted C2-C10 heterocyclyl or optionally C1-C10 heteroaryl substituted connected through a nitrogen； R3 is optionally substituted cyclopropyl, optionally substituted cyclobutyl, optionally substituted cyclopentyl, optionally substituted cyclohexyl, optionally substituted phenyl, optionally substituted adamantyl, optionally substituted azetidinyl, optionally substituted bicyclo [2,1,1] hexyl, [2,2,1] optionally substituted heptyl, optionally substituted bicyclo [2,2,2] octyl, optionally substituted bicyclo [3,2,1] octyl, optionally substituted bicyclo [3,1,1] heptyl, optio
