KIM, YONGGIL,CHO, NAHMRYUNE,KIM, YUNHEE,HEO, JOON,DONG, SEONMIN,JI, MI KYUNG,CHA, MAN-YOUNG,LEE, KIHO
申请号：
ES09755056
公开号：
ES2519090T3
申请日:
2009.05.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A piperazine compound represented by the formula (I): ** Formula ** or pharmaceutically acceptable salts thereof, wherein n is an integer from 2 to 6； R1 and R2 are the same or different and are independently selected from the group consisting of hydrogen, a hydroxyl group, a halogen, nitrogen dioxide, a straight or branched chain alkyl group with 1 to 4 carbon atoms, and a group straight or branched chain alkoxy with 1 to 4 carbon atoms； R3 is a C1-C2 alkylene； and R4 is selected from the group consisting of: (a) a C2-C6 dialkylamine, (b) an aromatic amine consisting of 5 to 9 members in which the ring is independently substituted with at least one of hydrogen, an alkyl C1-C6 aliphatic, a C3 to C10 cyclic alkyl, a C6-C10 aryl group and a halogen, (c) a heteroaromatic amine consisting of 5 to 9 members comprising at least one nitrogen atom as a constituent of the ring in which the ring is independently substituted with at least one of hydrogen, a C1-C6 aliphatic alkyl, a C3 to C10 cyclic alkyl, a C6-C10 aryl group and a halogen, (d) a heterocyclic ring consisting of 5 to 9 members comprising at least one nitrogen atom as a constituent of the ring in which the ring is independently substituted with at least one of hydrogen, a C1-C6 aliphatic alkyl, a C3 to C10 cyclic alkyl, a C6-C10 aryl group and a halogen, and (e) an integ heteroaromatic ring 5 to 9 members comprising at least one nitrogen atom as a constituent of the ring in which the ring is independently substituted with at least one of hydrogen, a C1-C6 aliphatic alkyl, a C3 to C10 cyclic alkyl, a C6-C10 aryl group and a halogen； and R4 is connected to the group R3 through a nitrogen atom therein.Un compuesto de piperazina representado por la fórmula (I):**Fórmula** o sales farmacéuticamente aceptables del mismo, en el que n es un número entero de 2 a 6； R1 y R2 son iguales o diferentes y se seleccionan de forma independiente del grupo que consiste en hidrógeno, un grupo hidróxilo, un halógeno, dióxido de nitró
