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COMPOSES CARBONYLES HETEROCYCLIQUES
专利权人:
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
DORSCH, DIETER,GERICKE, ROLF,MEDERSKI, WERNER,BEIER, NORBERT,LANG, FLORIAN
申请号:
CA2584465
公开号:
CA2584465C
申请日:
2005.04.04
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The invention relates to novel heterocyclic compounds of formula (I):(see formula I)in which R1 and R1a independently are an optionally substituted mono- orbicyclicsaturated, unsaturated or aromatic carbo- or heterocycle; D is O, NH or S; Wis CX orN; T and T' are CX, N or CR, with the proviso that T and T' are not both CR; Ris-C(=O)-N(R2)[C(R2)2]n R1a; X is H, Hal, A, OR2, N(R2)2, NO2, CN, COOR2,CON(R2)2,NR2COA, NR2SO2A, COR2 or SO2NR2; R2 is H, A, -[C(R3)2]n-Ar', -[C(R3)2]n-Het',-[C(R3)2]n-cycloalkyl, -[C(R3)2]-OR3, -[C(R3)2]n-COOA or -[C(R3)2]n N(R3)2; R3is Hor A; A is optionally branched and modified C1-10 alkyl; Ar' is optionallysubstitutedphenyl, naphthyl or biphenyl; Het' is an optionally substituted mono- orbicyclicsaturated, unsaturated or aromatic heterocycle; Hal is F, CI, Br or I, and nis 0, 1, 2or 3. Said compounds are SGK-inhibitors and can be used in the treatment ofSGK-related diseases and disorders such as diabetes, obesity, metabolicsyndrome(dyslipidemia), systemic and pulmonal hypertension, cardiovascular diseasesandrenal diseases, and generally for any kind of fibroses and inflammatoryprocesses.
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