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КОМПОЗИЦИИ И СПОСОБЫ ИММУНИЗАЦИИ С ПРИМЕНЕНИЕМ ЛИГАНДОВ CD1D
专利权人:
НОВАРТИС ВЭКСИНЕС ЭНД ДАЙЭГНОСТИКС СРЛ (IT)
发明人:
ГАЛЛИ Грация (IT)
申请号:
RU2014117946/15
公开号:
RU2014117946A
申请日:
2007.03.15
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A composition comprising α-antigen and glikoziltseramid grippa.2. Composition according to Claim. 1, wherein said α-glikoziltseramid represents α-galaktoziltseramid or analog.3. The composition according to claim. 2, wherein the analog of α-galaktoziltseramida selected from KRN7000, OCH and CRONY-101.4. Use of a composition according to any one of claims. 1-3 in the preparation of a medicament for preventing or treating virus infections grippa.5. A method of inducing an immune response in a patient, which method comprises administering to said patient an α-antigen and glikoziltseramida grippa.6. The method of claim. 5, wherein said influenza antigen and α-glikoziltseramid odnovremenno.7 administered. The method of claim. 5, wherein said influenza antigen and α-glikoziltseramid razdelno.8 or administered sequentially. A method of inducing long-term immunological memory against the antigen of influenza virus in a patient in need thereof, which method comprises administering to said patient one or more doses of the composition according to any one of claims. 1-3.9. A method according to claim. 8, wherein the method comprises administering a dose of the exciting and at least two booster doses, and wherein said booster dose is administered at intervals of more than one year.10. A method according to claim. 8, wherein the method does not include administering a booster dozy.11. The method of claim. 10 wherein the method comprises administering one excitatory dose sufficient to induce a protective immune response against subsequent virus infection grippa.12. A method according to claim. 8, wherein the amount and / or frequency of doses of the composition required for the patient to induce an immune response to the antigen further influenza virus reduced compared to the amount and / or frequency of doses of the composition1. Композиция, содержащая α-гликозилцерамид и антиген вируса гриппа.2. Композиция по п. 1, где указанный α-гликозилцерамид представляет собой α-галакто
来源网站:
中国工程科技知识中心
来源网址:
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