The present disclosure is directed to individual Aβ peptide immunogen constructs, peptide compositions comprising these Aβ peptide immunogen constructs and mixtures thereof, pharmaceutical compositions including vaccine formulations comprising these Aβ peptide immunogen constructs, with the individual Aβ peptide immunogen constructs having the N-terminus of the Aβ peptide as the B cell (B) epitopes linked through spacer residue(s) to heterologous T helper cell (Th) epitopes derived from pathogen proteins that act together to stimulate the generation of highly specific antibodies directed against the N-terminus of the Aβ peptide offering protective immune responses to patients at risk for, or with, Alzheimer’s Disease.本發明係有關於Aβ胜肽免疫原結構，含有此Aβ胜肽免疫原結構的胜肽組合物及其混合物，含有此胜肽免疫原結構之疫苗配方的藥學組成物，以具有Aβ胜肽N端的Aβ胜肽免疫原結構作為B細胞(B)抗原決定位，透過間隔子連接至源自病原蛋白的異源性T輔助細胞(Th)抗原決定位，其可共同刺激產生針對Aβ胜肽N端的高特異性抗體，以提供免疫反應，保護阿茲海默症患者或具罹患阿茲海默症風險的個體。
