The present disclosure is directed to alpha-synuclein (α-Syn) peptide immunogen constructs, compositions containing the constructs, antibodies elicited by the constructs, and methods for making and using the constructs and compositions thereof. The disclosed α-Syn peptide immunogen constructs contain a B cell epitope from α-Syn linked to a heterologous T helper cell (Th) epitope directly or through an optional heterologous spacer. The B cell epitope portion of the peptide immunogen constructs contain about 10 to about 25 amino acid residues of α-Syn, corresponding to the sequence from about the Glycine at position 111 (G111)to about the Asparagine at position 135 (D135) of full-length α-Syn. The α-Syn peptide immunogen constructs stimulate the generation of highly specific antibodies that are cross-reactive with the β-sheet of α-Syn as monomers, oligomers, and fibrils, but not the natural α-helix of α-Syn, offering therapeutic immune responses to hosts at risk for synucleinopathies.本發明有關於α-突觸核蛋白(α-Syn)胜肽免疫原結構、含此結構的組成物、此結構所誘發的抗體、以及製造及使用此結構及組成物的方法。α-Syn胜肽免疫原結構含有α-Syn的B細胞抗原決定位，其直接或透過選擇性異源連接子連接異源性T輔助細胞(Th)抗原決定位。胜肽免疫原結構的B細胞抗原決定位含有α-Syn的約10至約25個胺基酸，對應於全長α-Syn之自約第111個位置的甘胺酸(G111)至約第135個位置的天門冬胺酸(D135)的序列。α-Syn胜肽免疫原結構刺激高特異性抗體的產生，此高特異性抗體與為單體、寡聚物及原纖維之α-Syn的β摺疊，而非天然之α-螺旋的α-Syn交叉反應，對具罹患突觸核蛋白病風險的個體提供治療性免疫反應。
