The present invention is directed to novel heterologous promiscuous and artificial T helper cell epitopes (Th epitopes) designed to provide optimum immunogenicity of a target antigenic site. The disclosed Th epitopes, when covalently linked to a B cell epitope in a peptide immunogen construct, elicit a strong antibody response to the B cell epitope of the target antigenic site. The Th epitopes are immunosilent on their own, i.e., little, if any, of the antibodies generated by the peptide immunogen constructs will be directed towards the Th epitope, thus allowing a very focused immune response directed to the targeted antigenic site. The heterologous promiscuous Th epitopes provide effective and safe peptide immunogens that do not generate inflammatory, anti-self, cell-mediated immune responses following administration.本發明係有關於可提供目標抗原位點最佳免疫原性的新型異源性混雜、人工T輔助細胞抗原決定位(Th抗原決定位)。當本揭露Th抗原決定位與胜肽免疫原結構中的B細胞抗原決定位共價連接時，可誘發針對目標抗原位點B細胞抗原決定位的強烈抗體反應。Th抗原決定位本身為免疫沉默的，即利用胜肽免疫原結構產生的抗體很少(如果有的話)是針對Th抗原決定位，因此允許產生針對目標抗原位點非常集中的免疫反應。異源性混雜的Th抗原決定位可提供有效且安全的胜肽免疫原，在給予後不會產生發炎、抗自身、細胞介導的免疫反應。
