The present disclosure is directed to individual A β peptide immunogen constructs, peptide compositions comprising these A β peptide immunogen constructs and mixtures thereof, pharmaceutical compositions including vaccine formulations comprising these A β peptide immunogen constructs, with the individual A β peptide immunogen constructs having the N-terminus of the A β peptide as the B cell (B) epitopes linked through spacer residue(s) to heterologous T helper cell (Th) epitopes derived from pathogen proteins that act together to stimulate the generation of highly specific antibodies directed against the N-terminus of the A β peptide offering protective immune responses to patients at risk for, or with, Alzheimer’s Disease.本發明係有關於A β胜肽免疫原結構，含有此A β胜肽免疫原結構的胜肽組合物及其混合物，含有此胜肽免疫原結構之疫苗配方的藥學組成物，以具有A β胜肽N端的A β胜肽免疫原結構作為B細胞(B)抗原決定位，透過間隔子連接至源自病原蛋白的異源性T輔助細胞(Th)抗原決定位，其可共同刺激產生針對A β胜肽N端的高特異性抗體，以提供免疫反應，保護阿茲海默症患者或具罹患阿茲海默症風險的個體。
