Nav1.8 modulators are potentially useful for the treatment of a wide range of disorders, including pain.Claim 1: a compound of the formula (1) or a taut u00f3mero this, or a Salt or a solvate acceptable from the point of view of pharmaceutical Compound or taut u00f3mero where: one of X and y is c and the other is r u00b9 and Selects N； h, F, CL, and one cf u2083； R u00b2 and r u00b3 is selected from alkyl C u2083 u208b u2086, cycloalkyl c u2083 u208b u2086, Adamantyl and phenyl substituted with cn and, Optionally,Also replaced with one or two selected groups regardless of F -, CL -, - and - CN cf u2083； and the other R u00b2 and r u00b3 is selected from H and F； r u2074 is selected from h, F, cl and cf u2083； r u2075 is selected from alkyl c u2081 u208b u2086； c u2081 u208b u2086 alkyl substituted with a selected Group of - conh u2082, - With c u2081 u208b u2083 - (alkyl, alkyl c u2081 u208b u2083) u2082 where c u2081 u208b u2083 alkyl groups can be equal or different, - Oh,- c u2081 u208b u2083 or alkyl and cycloalkyl - oconh u2082； c u2083 u208b u2086, and phenyl； r u2076 is selected from H and alkyl c u2081 u208b u2083； or r u2075 and r u2076, together with the carbon Atom to which they are United, Can form a cycloalkyl portion of 3 to 6 members that can be optionally Merge to benzo r u2077 is h； or Methyl, or, when r u2075 r u2076 portion and not forming a cycloalkyl or cycloalkyl r u2075 benzo FUSED, and r u2077,Together with the Carbon and Nitrogen Atoms to which they are United, Can form a saturated Heterocyclic nitrogen monocyclic or bicyclic 4 to 6 members of 6 to 8 members can be replaced optionally with 1 or 2 groups selected from alkyl c u2081 u208b u2083, - Oh and - F.Los moduladores de NaV1.8 son potencialmente útiles para el tratamiento de un amplio rango de trastornos, en particular, del dolor. Reivindicación 1: Un compuesto de la fórmula (1) o un tautómero de este, o una sal o un solvato aceptables desde el punto de vista farmacéutico del compuesto
