Ofitserova Ekaterina Sergeevna (RU),Офицерова Екатерина Сергеевна (RU),Shklyarenko Artem Aleksandrovich (RU),Шкляренко Артем Александрович (RU),Chernyshev Vladimir Vasilevich (RU),Чернышев Владимир Ва
申请号：
RU2019130749
公开号：
RU0002709018C1
申请日:
2019.09.26
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to organic and medical chemistry, specifically to novel 1-benzoyl-substituted-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine derivatives of general formula I, where R=H, R1=phenyl (Ia) – 1-benzoyl-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d] pyrimidine； R=H, R1=2-bromophenyl (Ib) – 1-(2-bromobenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=2-methylphenyl (Ic) – 1-(2-methylbenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=2-methoxyphenyl (Id) – 1-(2-methoxybenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=3,4-dimethoxyphenyl (Ie) – 1-(3,4-dimethoxybenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=3-bromphhenyl (If) – 1-(3-bromobenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=3-methylphenyl (Ig) – 1-(3-methylbenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=3-methoxyphenyl (Ih) – 1-(3-methoxybenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=4-bromphhenyl (Ii) – 1-(4-bromobenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=4-methylphenyl (Ij) – 1-(4-methylbenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4 d]pyrimidine； R=H, R1=4-methoxyphenyl (Ik) – 1-(4-methoxybenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=2-furyl (Il) – 6-(methylthio)-1-(2-furoyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine； R=H, R1=2-thienyl (Im) – 6-(methylthio)-1-(2-thienylcarbonyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine. Invention also relates to a method of producing a compound of formula (I).EFFECT: obtaining novel heterocyclic compounds having antimicrobial activity.2 cl, 14 exИзобретение относится к области органической и медицинской химии, а именно: к новым производным 1-бензоилзамещенные-6-(метилтио)-4-хлор-1H-пиразоло[3,4-d]пиримидина общей формулы I, где R=H, R1=фенил (Iа) - 1-бензоил-6-(метилтио)-4-хлор-1H-пиразоло[3,4-d] пиримидин； R=H, R1=2-бромфенил (Iб) -
