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Heterocyclic compounds, medicines containing said compounds, use thereof and procedures for preparing them
专利权人:
Boehringer Ingelheim International GmbH
发明人:
HECKEL, Armin,FRATTINI, Sara,HAMPRECHT, Dieter,KLEY, Joerg
申请号:
ES12777930
公开号:
ES2645744T3
申请日:
2012.10.29
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
The compound of formula (IA), (IB) or (IC.1) ** Formula ** in which A indicates a bond, -CH2-, -CH2CH2- or -CH2-O-, R1 is selected from the group that It consists of hydrogen, C1-6 alkyl, C1-4-SO2- alkyl, C1-4-NH-CO- alkyl, H2N-CO-, H2N-C1-4- alkyl, H2N-C1-4-CO- alkyl, H2 C1-4-NH-CO- alkyl, Phenyl-CO-, Phenyl-CH2-CO-, Phenyl-CH2-, C1-6-CO- alkyl, C1-6 alkyl -O- C1-4-CO- alkyl, (CH3) 2N-C1-4 alkyl-, (CH3) 2N-C1-4 alkyl-NH-CO-, (CH3) 3N + -C 1-4 alkyl-NH-CO-, (CH3) N + -C 1-4 alkyl -N (C1-4 alkyl) -CO-, (CH3) 3N + -C2-4 alkyl, (CH3) 3N + -C 1-4 alkyl-CO-, H2N-C (NH) -NH-C1-6 alkyl- NH-CO-, C1-6-O-CO- alkyl, C1-6-O-CO-C1-4 alkyl, C1-6-O-CO-C1-4-CO- alkyl, C1- alkyl 6-O-CO-C 1-4 alkyl-NHCO-, C 1-6 alkyl-O-CO-NH-C 1-4 alkyl, C 1-6 alkyl-O-CO-NH-C 1-4 alkyl- C1-6-O-CO-NH alkyl C1-4 alkyl-NHCO-, HOCO C1-4 alkyl-, HOCO-C1-4 alkyl-CO-, HOCO-C1-4 alkyl-NH-CO-, H2N-CNH - and H2NC (NH) NH-C1-6-CO- alkyl, or R1 is selected from a group of formulas enu Next, (c1) to (c5): ** Formula ** R1b is C1-4 alkyl, R1s indicates C1-6 alkyl, X- indicates any anion that forms a pharmaceutically acceptable salt, L indicates a bridged group - CO-NH-C2-6-NH-CO- alkyl, -CO-C 1-6 alkyl-CO- or -C2-6 alkyl, forming a compound of formula (IC.1), whereby the molecular entities of formula (IC.1) connected by L may be identical or different, R2, R3, R4, R6, R7, R2a, R3a, R4a, R6a and R7a indicate hydrogen and the pharmacologically acceptable acid addition salts thereof.El compuesto de fórmula (IA), (IB) o (IC.1)**Fórmula** en la que A indica un enlace, -CH2-, -CH2CH2- o -CH2-O-, R1 se selecciona del grupo que consiste en hidrógeno, alquilo C1-6, alquilo C1-4-SO2-, alquilo C1-4-NH-CO-, H2N-CO-, H2N-alquilo C1-4-, H2N-alquilo C1-4-CO-, H2Nalquilo C1-4-NH-CO-, Fenil-CO-, Fenil-CH2-CO-, Fenil-CH2-, alquilo C1-6-CO-, alquilo C1-6 -O- alquilo C1-4-CO-, (CH3)2N-alquilo C1-4-, (CH3)2N-alquilo C1-4-NH-CO-, (CH3)3N+-alquilo C1-4-NH-CO-, (CH3)N+-alquilo C1-4-N(alquilo C1- 4)-CO-, (CH3)3N+-alquilo C2-4-, (CH3)3N+-a
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