UTILISATION D'OLIGOMERES D'ALGINATE POUR LE TRAITEMENT DE FIBROSE KYSTIQUE ET D'AUTRES TROUBLES ASSOCIES A UNE DEFICIENCE DE FONCTION DE CANAL IONIQUE CFTR
HANSSON, GUNNAR C.,ERMUND, ANNA,MYRSET, ASTRID HILDE,DESSEN, ARNE,ONSOYEN, EDVAR J,RYE, PHILIP D.
申请号：
CA2940560
公开号：
CA2940560A1
申请日:
2015.02.27
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention provides a method for the treatment of a condition in a human patient arising from or associated with a defective cystic fibrosis transmembrane conductance regulator(CFTR) ion channel and/or abnormal mucus which is attached to underlying epithelium, said method comprising administering an alginate oligomer,wherein at least 30% of the monomer residues of the alginate oligomer are G residues,to the patient in an amount sufficient to achieve a local concentration of the alginate oligomer of 1to 6% w/v at at least part of a mucosal surface with a defective CFTR ion channel and/or said abnormal mucus in the patient, thereby to result in at least partial detachment of mucus from said mucosal surface. In certain embodiments said condition is cystic fibrosis (CF), non- compound CFTR gene mutation heterozygosity, abnormal mucus clearance in the respiratory tract and/or breathing difficulties resulting from chronic particulate inhalation, COPD, chronic bronchitis, emphysema, bronchiectasis, asthma or chronic sinusitis, or a complication thereof.
