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Data from: Searching for diamonds in the apomictic rough: a case study involving Boechera lignifera (Brassicaceae)
- 负责人：
- DOI：
- doi:10.5061/dryad.933v0
- 摘要：
- cytological studies, microsatellite DNA analyses, geography, and morphology, we demonstrate that the apomictic populations are genetically quite divergent from
Data from: Allopolyploidy in the Wintergreen Group of tribe Gaultherieae (Ericaceae) inferred from low-copy nuclear genes
- 负责人：
- DOI：
- doi:10.5061/dryad.2gh0ht2
- 摘要：
- y, reproductive biology, and cytology, the results suggest that these clades arose through allopolyploid hybridization between lineages deep in the phylogeny but relative
Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis
- 负责人：
- 关键词：
- Cell Biology Microbiology Molecular Biology Physiology 59999 Environmental Sciences not elsewhere classified Ecology Science Policy Immunology Cancer Science Policy
- DOI：
- doi:10.6084/m9.figshare.1601892.v1
- 摘要：
- Wear particle-induced osteolysis is the leading cause of aseptic loosening, which is the most common reason for THA (total hip arthroplasty) failure and revision surgery. Although existing studies suggest that osteoblast apoptosis induced by wear debris is involved in aseptic loosening, the underlying mechanism linking wear particles to osteoblast apoptosis remains almost totally unknown. In the present study, we investigated the effect of autophagy on osteoblast apoptosis induced by CoCrMo metal particles (CoPs) in vitro and in a calvarial resorption animal model. Our study demonstrated that CoPs stimulated autophagy in osteoblasts and PIO (particle-induced osteolysis) animal models. Both autophagy inhibitor 3-MA (3-methyladenine) and siRNA of Atg5 could dramatically reduce CoPs-induced apoptosis in osteoblasts. Further, inhibition of autophagy with 3-MA ameliorated the severity of osteolysis in PIO animal models. Moreover, 3-MA also prevented osteoblast apoptosis in an antiautophagic way when tested in PIO model. Collectively, these results suggest that autophagy plays a key role in CoPs-induced osteolysis and that targeting autophagy-related pathways may represent a potential therapeutic approach for treating particle-induced peri-implant osteolysis.
Data from: Individual inversions or their combinations: which is the main selective target in a natural population of Drosophila subobscura?
- 负责人：
- DOI：
- doi:10.5061/dryad.1h7gr
- 摘要：
- chromosomes of the karyotype. For all these reasons it can be assumed that, at the cytological level, the individual inversions rather than their combinations
Data from: Are buffalograss (Buchlo? dactyloides) cytotypes spatially and ecologically differentiated?
- 负责人：
- DOI：
- doi:10.5061/dryad.nc38t01
- 摘要：
- is typically poorly understood. This study aims to establish the geographic distribution of cytotypes within buffalograss (Buchlo? dactyloides), and to assess
Cylindrospermopsin toxicity in mice following a 90-d oral exposure
- 负责人：
- 关键词：
- Cell Biology Biochemistry Genetics Pharmacology 59999 Environmental Sciences not elsewhere classified 39999 Chemical Sciences not elsewhere classified Marine Biology 60506 Virology
- DOI：
- doi:10.6084/m9.figshare.6182216.v1
- 摘要：
- (i.p.) route of administration and confirmed this pattern of toxicity with changes in liver enzyme activities and histopathology consistent with hepatic injury and adverse renal
The E3-ubiquitin ligase adaptor protein Skp1 is glycosylated by an evolutionarily conserved pathway that regulates protist growth and development.pdf
- 负责人：
- 关键词：
- Cell Biology 60102 Bioinformatics Microbiology Parasitology 60307 Host-Parasite Interactions 60502 Infectious Agents 110309 Infectious Diseases Pathology 60411 Population, Ecological and Evolutionary Genetics 60109 Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
- DOI：
- doi:10.6084/m9.figshare.5505661.v1
- 摘要：
- , based on mass spectrometry, and that assembly of the first three sugars is dependent on Toxoplasma homologs of Gnt1 and PgtA. Reconstitution
Data from: Whole genome duplication in coast redwood (Sequoia sempervirens) and its implications for explaining the rarity of polyploidy in conifers
- 负责人：
- DOI：
- doi:10.5061/dryad.7nb70
- 摘要：
- ical and cytological data, but it remains unclear how Sequoia became polyploid and why this lineage overcame an apparent gymnosperm barrier to whole-genome duplication
A novel role for the 3\u2032-5\u2032 exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth
- 负责人：
- 关键词：
- Cell Biology Biochemistry Genetics Molecular Biology 69999 Biological Sciences not elsewhere classified Developmental Biology
- DOI：
- doi:10.6084/m9.figshare.3830103.v2
- 摘要：
- In a complex organism, cell proliferation and apoptosis need to be precisely controlled in order for tissues to develop correctly. Excessive cell proliferation can lead to diseases such as cancer. We have shown that the exoribonuclease Dis3L2 is required for the correct regulation of proliferation in a natural tissue within the model organism Drosophila melanogaster. Dis3L2 is a member of a highly conserved family of exoribonucleases that degrade RNA in a 3\u2032-5\u2032 direction. We show that knockdown of dis3L2 in the Drosophila wing imaginal discs results in substantial wing overgrowth due to increased cellular proliferation rather than an increase in cell size. Imaginal discs are specified in the embryo before proliferating and differentiating to form the adult structures of the fly. Using RNA-seq we identified a small set of mRNAs that are sensitive to Dis3L2 activity. Of the mRNAs which increase in levels and are therefore potential targets of Dis3L2, we identified 2 that change at the post-transcriptional level but not at the transcriptional level, namely CG2678 (a transcription factor) and pyrexia (a TRP cation channel). We also demonstrate a compensatory effect between Dis3L2 and the 5\u2032-3\u2032 exoribonuclease Pacman demonstrating that these 2 exoribonucleases function to regulate opposing pathways within the developing tissue. This work provides the first description of the molecular and developmental consequences of Dis3L2 inactivation in a non-human animal model. The work is directly relevant to the understanding of human overgrowth syndromes such as Perlman syndrome.
A novel role for the 3\u2032-5\u2032 exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth
- 负责人：
- 关键词：
- Cell Biology Biochemistry Genetics Molecular Biology 69999 Biological Sciences not elsewhere classified Developmental Biology
- DOI：
- doi:10.6084/m9.figshare.3830103
- 摘要：
- In a complex organism, cell proliferation and apoptosis need to be precisely controlled in order for tissues to develop correctly. Excessive cell proliferation can lead to diseases such as cancer. We have shown that the exoribonuclease Dis3L2 is required for the correct regulation of proliferation in a natural tissue within the model organism Drosophila melanogaster. Dis3L2 is a member of a highly conserved family of exoribonucleases that degrade RNA in a 3\u2032-5\u2032 direction. We show that knockdown of dis3L2 in the Drosophila wing imaginal discs results in substantial wing overgrowth due to increased cellular proliferation rather than an increase in cell size. Imaginal discs are specified in the embryo before proliferating and differentiating to form the adult structures of the fly. Using RNA-seq we identified a small set of mRNAs that are sensitive to Dis3L2 activity. Of the mRNAs which increase in levels and are therefore potential targets of Dis3L2, we identified 2 that change at the post-transcriptional level but not at the transcriptional level, namely CG2678 (a transcription factor) and pyrexia (a TRP cation channel). We also demonstrate a compensatory effect between Dis3L2 and the 5\u2032-3\u2032 exoribonuclease Pacman demonstrating that these 2 exoribonucleases function to regulate opposing pathways within the developing tissue. This work provides the first description of the molecular and developmental consequences of Dis3L2 inactivation in a non-human animal model. The work is directly relevant to the understanding of human overgrowth syndromes such as Perlman syndrome.
