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Data from: Rapid quantitative pharmacodynamic imaging by a novel method: theory, simulation testing and proof of principle
- 负责人：
- DOI：
- doi:10.5061/dryad.s3443
- 摘要：
- Pharmacological challenge imaging has mapped, but rarely quantified, the sensitivity of a biological system to a given drug. We describe
Population pharmacokinetic\/pharmacodynamic modeling: evaluation of maximum likelihood expectation maximization method in ADAPT 5
- 负责人：
- 关键词：
- Biomedical Engineering population PK\/PD maximum likelihood expectation maximization IVGTT minimal model ADAPT
- DOI：
- doi:10.25549/usctheses-m143
- 摘要：
- pharmacokinetic / pharmacodynamic studies. Two detailed simulation studies were conducted using a one compartment pharmacokinetic model with spar
Data from: The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging
- 负责人：
- DOI：
- doi:10.5061/dryad.h37j22d
- 摘要：
- Objective: To determine the efficacy and safety of non-pharmacological interventions for orthostatic hypotension (OH) secondary to aging. Methods
Data from: Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and r
- 负责人：
- Lammens, Lieve
- DOI：
- doi:10.5061/dryad.5vv774m
- 摘要：
- ous solid dispersion (ASD) formulation was developed. As this formulation results in improved systemic absorption, the pharmacokinetic and toxicological profile
Data from: Calcium imaging with genetically encoded sensor Case12: facile analysis of ?7/?9 nAChR mutants
- 负责人：
- DOI：
- doi:10.5061/dryad.4k831
- 摘要：
- Elucidation of the structural basis of pharmacological differences for highly homologous ?7 and ?9 nicotinic acetylcholine receptors (nAChRs) may sh
Data from: Intrinsically regulated learning is modulated by synaptic dopamine signaling
- 负责人：
- DOI：
- doi:10.5061/dryad.g5f7v1j
- 摘要：
- loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this lear
Data from: Developmental expression of drug metabolizing enzymes: impact on disposition in neonates and young children
- 负责人：
- DOI：
- doi:10.5061/dryad.71pp6
- 摘要：
- -dependent changes in other physiological factors impacting drug disposition, can be integrated into physiologically-based pharmacokinetic models. Such models ha
\u2022\tRegulatory requirement for drug development and approval in United States: review
- 负责人：
- 关键词：
- 111701 Aboriginal and Torres Strait Islander Health 111001 Aged Care Nursing 111702 Aged Health Care 110301 Anaesthesiology 110901 Autonomic Nervous System 111501 Basic Pharmacology Biomarkers 110601 Biomechanics 111201 Cancer Cell Biology 111202 Cancer Diagnosis
- DOI：
- doi:10.6084/m9.figshare.3381274.v1
- 摘要：
- , the United States Food andDrug Administration (FDA) was formed. The provisions ofthe FDA are intended to ensure that:
Data from: Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy
- 负责人：
- DOI：
- doi:10.5061/dryad.g003051
- 摘要：
- golodirsen; Part 2 is an ongoing, open-label evaluation. Safety and pharmacokinetics were primary and secondary objectives of Part 1. Primary biolog
Data from: Phased whole-genome genetic risk in a family quartet using a major allele reference sequence
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.34q0d
- 摘要：
- for inherited thrombophilia and informing the appropriate pharmacological therapy. These ethnicity-specific, family-based approaches to interpretation of genetic var
