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Data from: Generalized polyspike train: an EEG biomarker of drug-resistant idiopathic generalized epilepsy
- 负责人：
- 关键词：
- epilepsy;EEG
- DOI：
- doi:10.5061/dryad.51d718j
- 摘要：
- Objective: To identify clinical and EEG biomarkers of drug resistance in adults with idiopathic generalized epilepsy. Methods: We conducted
Data from: Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery
- 负责人：
- DOI：
- doi:10.5061/dryad.8r351
- 摘要：
- that will hopefully fuel future TB drug discovery and target validation programs alike.
Data from: Resource limitation prevents the emergence of drug resistance by intensifying within-host competition
- 负责人：
- DOI：
- doi:10.5061/dryad.v2q3v
- 摘要：
- Slowing the evolution of antimicrobial resistance is essential if we are to continue to successfully treat infectious diseases. Whether a drug
Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex
- 负责人：
- DOI：
- doi:10.6084/m9.figshare.91540.v2
- 摘要：
- in the blood based on an individual\u2019s motivational state together with the pharmacokinetic properties of the drug. Here we describe a reliable low-cost
Data from: Clinical trial registration, reporting, publication and FDAAA compliance: a cross-sectional analysis and ranking of new drugs approved
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.t8n07
- 摘要：
- l clinical trials submitted to the Food and Drug Administration (FDA) for drugs approved in 2012, sponsored by large biopharmaceutical companies. Data sources: Inf
Data from: Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
- 负责人：
- DOI：
- doi:10.5061/dryad.86088n1
- 摘要：
- at the systems level. In contrast, predicted drug–target interactions reflect more appropriately brain region related neurotransmitter response. In conclusion
Data from: Aggressive chemotherapy and the selection of drug resistant pathogens
- 负责人：
- DOI：
- doi:10.5061/dryad.09qc0
- 摘要：
- managed by using drugs to rapidly eliminate target pathogens from patients so as to minimize the probability that pathogens acquire resistance de novo
Data from: The impact of within-host ecology on the fitness of a drug-resistant parasite
- 负责人：
- 关键词：
- rodent malaria;fitness cost;within-host competition;Drug resistance;malaria;Plasmodium chabaudi
- DOI：
- doi:10.5061/dryad.1g2n6d2
- 摘要：
- Background and objectives: The rate of evolution of drug resistance depends on the fitness of resistant pathogens. The fitness of resistant pathoge
Data from: Immunotherapy-related adverse events (irAEs): extraction from FDA drug labels and comparative analysis
- 负责人：
- DOI：
- doi:10.5061/dryad.fg6kt38
- 摘要：
- ween ICIs and non-ICI drugs. irAEs were resulted from both on- and off-target effects: irAE profiles were more similar for ICIs with same target than diffe
Human Lim Domain Kinase 1 (Limk1), Kinase Domain; A Target Enabling Package
- 负责人：
- 关键词：
- drug target protein target enabling package disease structure cancer neuropsychiatry neuro neurological genetic disorders metabolic diseases
- DOI：
- doi:10.5281/zenodo.1287260
- 摘要：
- e we present a target enabling package for the therapeutic target LIMK1. We include crystal structures of BMPR2, LIMK1, LIMK2 and the LIMK1-cofilin complex
