Godwin, Antony Robert,Pedone, Elisa,Choi, Ji-Won,Shaunak, Sunil,Brocchini, Stephen James
申请号：
AU2010257308
公开号：
AU2010257308B2
申请日:
2010.12.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010257308B220120112.pdf#####ABSTRACT Novel biologically active compounds of the general formula (I) in which one of X and X' represents a polymer, and the other represents a hydrogen atom； each Q independently represents a linking group； W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety； or, if X' represents a polymer, X-Q-W- together may represent an electron withdrawing group； and in addition, if X represents a polymer, X' and electron withdrawing group W together with the interjacent atoms may form a ring； each of Z' and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety； or ZI and Z 2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties； A is a C1.5 alkylene or alkenylene chain； and B is a bond or a C1 .4 alkylene or alkenylene chain； are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.
