Stephen James Brocchini,Antony Robert Godwin,Elisa Pedone,Ji-Won Choi,Sunil Shaunak
申请号：
US14444859
公开号：
US09439974B2
申请日:
2014.07.28
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom each Q independently represents a linking group W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via an amine group or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two amine groups A is a C1-5 alkylene or alkenylene chain and B is a bond or a C1-4 alkylene or alkenylene chain are formed by conjugating a suitable polymer to a suitable biologically active molecule via amine groups in said molecule, preferably via a disulphide bridge.
