BROCCHINI STEPHEN,BRYANT PENNY,CONG YUEHUA,CHOI JI WON,GODWIN ANTONY,POWELL KEITH
申请号：
IN790/DELNP/2010
公开号：
IN281873B
申请日:
2010.02.04
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The invention provides a novel process for conjugating a polymer, especially PEG, to a protein or peptide, which comprises reacting a polymeric conjugation reagent with a protein or peptide containing a polyhistidine tag under conditions such that conjugation occurs via said polyhistidine tag. The resulting conjugates are novel. The invention further relates to novel conjugates of the general formula (I) in which one of X and X" represents a polymer, and the other represents a hydrogen atom each Q independently represents a linking group W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety or, if X" represents a polymer, X-Q-W- together may represent an electron withdrawing group and in addition, if X represents a polymer, X" and electron withdrawing group W together with the interjacent atoms may form a ring Z represents a protein or a peptide linked to A and B via respective histidine residues A is a C1-5 alkylene or alkenylene chain and B is a bond or a C1-4 alkylene or alkenylene chain.
