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Conjugated biological molecules and their preparation
专利权人:
发明人:
申请号:
EP09167191.7
公开号:
EP2133099B1
申请日:
2004.07.12
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Novel compounds of the general formula in which one of X and X represents a polymer, and the other represents a hydrogen atom each Q independently represents a linking group W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety or, if X represents a polymer, X-Q-W- together may represent an electron withdrawing group and in addition, if X represents a polymer, X and electron withdrawing group W together with the interjacent atoms may form a ring Z 1 and Z 2 independently represents a protein, each of which is linked to A and B via a nucleophilic moiety, or Z 1 and Z 2 together represent a single protein which is linked to A and B via two nucleophilic moieties, each of said nucleophilic moieties being derived from an amine group A is a C 1-5 alkylene or alkenylene chain and B is a bond or a C 1-4 alkylene or alkenylene chain are formed by conjugating a suitable polymer to a protein via nucleophilic groups in said protein.
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