GODWIN, ANTONY ROBERT,PEDONE, ELISA,CHOI, JI-WON,BROCCHINI, STEPHEN JAMES
申请号：
PL10175140
公开号：
PL2253330T3
申请日:
2004.07.12
申请国别(地区):
PL
年份:
2016
代理人:
摘要：
Novel compounds of the general formula in which one of X and X' represents a polymer, and the other represents a hydrogen atom； each Q independently represents a linking group； W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety； or, if X' represents a polymer, X-Q-W- together may represent an electron withdrawing group； and in addition, if X represents a polymer, X' and electron withdrawing group W together with the interjacent atoms may form a ring； Z 1 and Z 2 independently represents a protein, each of which is linked to A and B via a nucleophilic moiety, or Z 1 and Z 2 together represent a single protein which is linked to A and B via two nucleophilic moieties, each of said nucleophilic moieties being derived from an amine group； A is a C 1-5 alkylene or alkenylene chain； and B is a bond or a C 1-4 alkylene or alkenylene chain； are formed by conjugating a suitable polymer to a protein via nucleophilic groups in said protein.
