Methods, composition, and intermediates are disclosed that are useful for making 4-Tetra2olyl-4-phenylpiperidine Compounds according to Formula (I), where Ar1 Is -C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups Ar2 is phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups Z1 and Z2 are each independently a -(C1-C4 alkyl) group R1 is -(CH2)nC(O)N(R3)(R4) where R3 and R4 are each independently H or -(C1-C4 alkyl) R2 is halogen, -C1-C3 alkyl, -O- (C1-C3 alkyl), -NH(C1-C3 alkyl) or -N(C1-C3 alkyl)2 n is an integer ranging from 1 to 4 m is an integer ranging from 0 to 4 and, in certain embodiments, the phenyl moiety attached to the 4-position of the piperidine ring of a compound according to Formula (I) can be optionally substituted with one or mor R2 groups.
