LAWSON, John David,SABAT, Mark,SCORAH, Nicholas,SMITH, Christopher,VU, Phong H.,WANG, Haixia
申请号：
ES14719130
公开号：
ES2624439T3
申请日:
2014.03.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula 1, ** Formula ** a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer, wherein: R1 is selected from hydrogen, halo, -CN, C1-4 alkyl, C1-4 haloalkyl and -OR14； each of R2 and R3 is independently selected from hydrogen, halo, -CN, R6, and R7, or R2 and R3, together with the carbon atoms to which they are attached, form a benzene ring or a pyridine ring in wherein the benzene ring is optionally substituted with one to four substituents independently selected from halo, -CN, R6 and R7, and the pyridine ring is optionally substituted with one to three substituents independently selected from halo, -CN, R6 and R7； R4 has the formula in which it indicates a point of attachment； L is selected from -O-, -CH2O- and -N (R4e) -； R4a is selected from -CH2R5 and ethenyl optionally substituted with one to three substituents independently selected from halo, cyano and R7； and (a) R4c is hydrogen, R4e is selected from hydrogen and C1-4 alkyl when L is -N (R4e) -, and R4b and R4d, together with a nitrogen atom and the carbon atoms to which R4b, R4c and R4d are attached respectively, form a pyrrolidine ring or a piperidine ring, each ring being optionally substituted with one to six substituents independently selected from halo, C1-4 alkyl and C1-4 haloalkyl； or (b) R4b is selected from hydrogen and C1-4 alkyl, R4d is hydrogen, L is -N (R4e) -, and R4c and R4e, together with the carbon atoms and a nitrogen atom to which R4c, R4d and R4e are attached respectively, form a pyrrolidine ring or a piperidine ring, each ring being optionally substituted with one to six substituents independently selected from halo, C1-4 alkyl and C1-4 haloalkyl； or (c) R4d is hydrogen, R4e is selected from hydrogen and C1-4 alkyl when L is -N (R4e) -, and R4b and R4c, together with the nitrogen and carbon atoms to which R4b and R4c are respectively attached , they form a pyrrolidine ring or a piperidine ring, each ring being optionally substituted with on
