BONNERT Rodzher Viktor (GB),БОННЕРТ Роджер Виктор (GB),MAKINALLI Tomas (GB),МАКИНАЛЛИ Томас (GB),TOM Stiven (GB),ТОМ Стивен (GB),VADA Khiroki (GB),ВАДА Хироки (GB),BONNERT RODZHER VIKTOR,БОННЕРТ Роджер Виктор,MAKINALLI TOMAS,МАКИНАЛЛИ Томас,TOM STIVEN,ТОМ Стивен,VADA KHIROKI,ВАДА Хироки
申请号：
RU2009140465/04
公开号：
RU0002475487C2
申请日:
2008.05.06
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: claimed invention relates to novel derivatives of imidazo[4,5-c]chinoline of general formula or to its pharmaceutically acceptable salts, where R1 represents straight-chained C1-C6alkyl, possibly substituted with one substituent, selected from C1-C3alkoxy； Z1 represents C2-C6alkylene； X1 represents NR5 or >；NCOR5； Y1 represents C1-C6alkylene； R3 represents C1-C6alkyl, possibly substituted with C1-C6alkoxy； R5 represents hydrogen, piperidinyl, possibly substituted by piperidinyl nitrogen with group R10, group C1-C6alkyl, where the last group is possibly substituted with one substituent, independently selected from NR7R8 or R9； or R5 represents C1-C6alkylene, which can be bound with carbon atom in C2-C6alkylene group Z1 with formation of piperidine ring； each of R7 and R8 independently represents tetrahydropyranyl, piperidinyl, possibly substituted by piperidinyl nitrogen atom with group R10a, C1-C6alkyl, where the last group is possibly substituted with one group, independently selected from OR12； or R7 and R8 together with nitrogen atom, to which they are bound, form 4-7-membered saturated heterocyclic ring, selected from asetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azepanyl, 1,4-oxazepanyl and 1,4-diazepanyl, where heterocyclic ring is possibly substituted with one or two substituents, independently selected from S(O)qR15, OR15, CO2R15, COR15, CONR15R16, NR15CO2R16, pyrimidinyl and C1-C6alkyl, where the last group is possibly substituted with one group, independently selected from OR18 and CO2R18； R9 represents S(O)qR20； R10 and R10a independently represent COR2 or group C1-C6alkyl； each of R12, R15, R16, R18, R20 and R24 independently represents hydrogen or C1-C6alkyl； q equals 2； m and n both equal 0； and A represents phenyl. Invention also relates to method of obtaining formula (I) compound, based on it pharmaceutical composition, and to method of treating said pathological conditions.EFFECT: obtai
