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Derivados de piperidil-2,6-diona usados para inhibir la liberación del factor de necrosis tumoral de las células
专利权人:
TIAN JIN HEMAY BIO-TECH CO.; LTD.
发明人:
ZHANG, HESHENG
申请号:
ES05785096
公开号:
ES2401281T3
申请日:
2005.09.13
申请国别(地区):
ES
年份:
2013
代理人:
摘要:
A piperidine derivative-2,6-dione, or organic or inorganic salts of this, the derivative is of the general formula (I) wherein n is 1, 2, 3, 4, 5 or 6 R1 represents one to four of the same or different substituents selected from F, Cl, Br, C1-4 alkyl, OH, OC1-4 alkyl, NO2, NHC (O) C1-4 alkyl, NH2, NH (C1-4 alkyl ), N (C1-4 alkyl) 2 R2 represents OR3 NR3R4, N (R3) COR4, O2CR5 R3 and R4 represent independently at each occurrence H or C1-4 alkyl R5 represents CHR6NR7R8, CHR6NR9C (O) CHR10NR7R8, W or CHR6NR9C (O) W R6, R9, R10 represent independently at each occurrence H, or C1-4 alkyl R7 and R8 represent independently at each occurrence H, or C1-4 alkyl, or R7 and R8 taken together represent 1,3-propylene, 1,4-butylene, 1,5-pentylene or 1,6-hexylene optionally substituted by OH, COOH, C (O) NH2, NHC (O) R13, NH2, NHR14, NR15R16, NHC (O) NH2, NHC (NH) NH2, OR 17, SR18, phenyl, or substituted phenyl R13, R14, R15, R16, R17 and R18 independently represent at each occurrence H, or C1-4 alkyl and W represents a saturated or unsaturated four, five, six members, seven members, eight members heterocycle.Un derivado de piperidina-2,6-diona, o sales orgánicas o inorgánicas de este, el derivado es de la fórmula general (I), en donde n es 1, 2, 3, 4, 5 o 6 R1 representa de uno a cuatro de los mismos o diferentes sustituyentes seleccionados de F, Cl, Br, C1-4alquilo, OH, OC1-4 alquilo, NO2, NHC(O)C1-4 alquilo, NH2, NH(C1-4 alquilo), N(C1-4 alquilo)2 R2 representa OR3 NR3R4, N(R3)COR4, O2CR5 R3 y R4 representan independientemente en cada aparición H o C1-4 alquilo R5 representa CHR6NR7R8, CHR6NR9C(O)CHR10NR7R8, W o CHR6NR9C(O)W R6, R9, R10 representan independientemente en cada aparición H, o C1-4alquilo R7 y R8 representan independientemente en cada aparición H, o C1-4alquilo, o R7 y R8 tomados juntos representan 1,3-propileno, 1,4-butileno, 1,5-pentileno, o 1,6-hexileno opcionalmente sustituido por OH, COOH,C(O)NH2, NHC(O)R13, NH2, NHR14, NR15R16, NHC(O)NH2, NHC(NH)NH2, OR17, SR18
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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