DAVID GEORGE ALLEN,DIANE MARY COE,CAROLINE MARY COOK,ANTHONY WILLIAM JAMES COOPER,MICHAEL DENNIS DOWLE,CHRISTOPHER DAVID EDLIN,JULIE NICOLE HAMBLIN,MARTIN REDPATH JOHNSON,PAUL SPENCER JONES,MIKA KRIST
申请号：
IS7913
公开号：
IS2795B
申请日:
2005.06.23
申请国别(地区):
IS
年份:
2012
代理人:
摘要：
The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl or -(CH2)2OH； R2 is a hydrogen atom (H), methyl or C1fluoroalkyl； R3a is a hydrogen atom (H) or C1-3alkyl； R3 is optionally substituted branched C3-6alkyl, optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc): in which n1 and n2 independently are 1 or 2； and Y is O, S, SO2, or NR4； and wherein Het is of sub-formula (i), (ii), (iii), (iv) or (v): The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
