JAMES M. ALLEN,NEAL S. VAN HOEVEN,JIN ZHONG LI,DEREK D. SLOAN,THOMAS W. DUBENSKY JR.
申请号:
PT13194273
公开号:
PT2770061T
申请日:
2010.07.22
申请国别(地区):
PT
年份:
2018
代理人:
摘要:
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).