ALLEN, JAMES M.,VAN HOEVEN, NEAL S.,LI, JIN ZHONG,SLOAN, DEREK D.,DUBENSKY, THOMAS W. JR.
申请号:
PL10737715
公开号:
PL2456786T5
申请日:
2010.07.22
申请国别(地区):
PL
年份:
2017
代理人:
摘要:
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).