ALLEN, JAMES, M.,VAN HOEVEN, NEAL, S.,LI, JIN ZHONG,SLOAN, DEREK, D.,DUBENSKY, THOMAS W., JR.
申请号:
HK15102018.7
公开号:
HK1201557A
申请日:
2015.02.27
申请国别(地区):
HK
年份:
2015
代理人:
摘要:
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).