ALLEN, JAMES M.,VAN HOEVEN, NEAL S.,LI, JIN ZHONG,SLOAN, DEREK D.,DUBENSKY, THOMAS W.
申请号：
HRP20140327
公开号：
HRP20140327T1
申请日:
2014.04.04
申请国别(地区):
HR
年份:
2014
代理人:
摘要：
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant； and (b) a lentiviral vector genome comprising a sequence of interest； wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).
