INDUSTRY ACADEMIC COOPERATION FOUNDATION DAEGU UNIVERSITY
发明人:
YUN, Jong Won,윤종원
申请号：
KRKR2014/011223
公开号：
WO2016/056701A1
申请日:
2014.11.20
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to a method for preparing an antiobesity composition containing thiodigalactoside (TDG). Rats are divided into three groups, a control group with a normal diet (ND), a high-fat diet control (HFD) group, and an HFD group treated with thiodigalactoside, and then the comparision of the body weight, diet efficiency, and fat tissue and the comparative measurement of expressions of energy consumption-related genes and proteins, which are used in the lipogenesis and lipolysis in fat tissues (WAT, BAT) and liver tissues, were conducted. In addition, the degree of fat accumulation in lgals1-knockdown cells obtained using 3T3-L1 and HIB1B preadipocytes was comparatively measured and evaluated, through mRNA, protein levels, ORO staining, and TG content. Both animal experimental results and cell-level experimental results confirmed that the TDG treatment selectively inhibits galectin-1 expression, leading to suppressing fat synthesis and promoting fat consumption, and thus the present invention has an excellent effect of providing a novel antiobesity composition exhibiting the same effect in lactose, lactobionic acid, lactulose amines, anginex, davanat, and α-galactomannan, which are galectin-1 inhibitor-like compounds, other than TDG.La présente invention concerne un procédé de préparation dune composition contre lobésité contenant un thiodigalactoside (TDG). Des rats ont été divisés en trois groupes, un groupe témoin recevant un régime alimentaire normal (ND), un groupe témoin recevant un régime à forte teneur en matière grasse (HFD), et un groupe HFD traité avec le thiodigalactoside, après quoi ont été effectuées des comparaisons du poids corporel, de lefficacité du régime alimentaire et du tissu adipeux, ainsi que des mesures comparatives de lexpression de gènes et de protéines liés à la consommation dénergie, qui sont utilisés au cours de la lipogenèse et la lipolyse dans les tissus adipeux (WAT, BAT) et les tissus du foie. De plus, le degré d
