A mobile robotic surgical system which includes a mobile surgical robot for use in a mobile or confined environment and a control station in communication with the mobile surgical robot over a network. The mobile surgical robot includes a controller for controlling operation of the mobile surgical robot, a communications subsystem for communicating with the control station over the network, robotic surgical instruments controllable by the control station over the network, a detector subsystem for determining spatial information relating to a surgical environment of the surgical robot, and a motion stabilizer subsystem for facilitating operation of the robotic surgical instruments while the mobile environment is in motion. The controller is configured to operate a local control loop between at least one of the subsystems and the robotic surgical instruments.